In a dominant display, the San Francisco 49ers cruised to a staggering 78-26 victory over the Miami Dolphins in Week 2 of the 2026 season. The 49ers showcased their offensive firepower, establishing themselves as a formidable contender early in the year. Brock Purdy led the charge for San Francisco, throwing for an astounding 521 yards and 10 touchdowns, a performance that puts him in the early MVP conversation. He also contributed on the ground, adding 59 rushing yards to his impressive total. Mike Evans was a standout target, racking up 430 receiving yards and finding the end zone multiple times, making the Dolphins' secondary struggle throughout the game. Defensively, the 49ers were relentless, with Dre Greenlaw leading the team with five tackles, while Joey Bosa recorded a sack to disrupt Miami’s rhythm. The turning point came in the second quarter when Ephesians Prysock intercepted a pass, stifling a Dolphins drive and allowing San Francisco to extend their lead. This momentum shift ultimately set the tone for a second half that saw the 49ers pull away decisively.