The Buffalo Bills rolled to a 45-26 win over the Detroit Lions on Sunday, turning a Week 2 matchup of playoff hopefuls into a statement afternoon in Orchard Park. Buffalo controlled the scoreboard from the air and never let Detroit's explosive ground game dictate the terms. The Bills move to 1-1 in the win column of this early season stretch, while the Lions leave with plenty to clean up despite a historic individual performance. Josh Allen was the engine, throwing for 281 yards and four touchdowns while spreading the ball around the field with the kind of command that has defined his career. DJ Moore was his most productive target, hauling in 104 receiving yards and consistently winning on the perimeter to keep the chains moving. Detroit's answer was Jahmyr Gibbs, who ripped off a staggering 320 rushing yards in a performance that will lead every highlight package in the league. The problem for the Lions was arithmetic: Gibbs' brilliance produced yards, but Allen's four scoring strikes produced points. Defensively, Buffalo made the plays that mattered when the game hung in the balance. Greg Rousseau was a menace off the edge with two sacks, repeatedly forcing Detroit off schedule and into obvious passing situations. Terrel Bernard's interception was the swing moment, snuffing out a Lions drive and handing the ball back to an offense that was already in rhythm. Dee Alford led the way with five total tackles, and the Bills' ability to generate negative plays ultimately turned Gibbs' 320-yard afternoon into a footnote rather than a formula for victory.