The Denver Broncos dominated the San Francisco 49ers with a commanding 34-6 victory in Week 4 of the 2026 season. This win solidifies the Broncos as a formidable force in the league, showcasing their offensive prowess while the 49ers struggle to find their rhythm. Bo Nix led the charge for Denver, throwing for an impressive 386 yards and three touchdowns, proving to be a constant threat in the air. Courtland Sutton shined as his top target, racking up 116 receiving yards and making key catches that extended drives and put points on the board. Meanwhile, the 49ers' offense faltered, with Christian McCaffrey managing only 47 rushing yards against a stout Broncos defense. Defensively, the Broncos were relentless, with standout performances that stifled San Francisco's attack. JL Skinner made a pivotal interception, halting a potential scoring drive and shifting momentum firmly in favor of Denver. The game turned decisively in the second quarter when the Broncos scored back-to-back touchdowns, leaving the 49ers reeling and unable to recover as they struggled to find answers on both sides of the ball.