The San Francisco 49ers dominated the Miami Dolphins in a resounding 66-26 victory in Week 2 of the 2026 season. With this win, the 49ers establish themselves as a formidable force early in the season, showcasing their offensive prowess and defensive capabilities against a struggling Dolphins squad. Leading the charge for San Francisco was quarterback Brock Purdy, who threw for an impressive 429 yards and four touchdowns. Wide receiver Mike Evans was a standout target, racking up 254 receiving yards, while De'Von Achane of the Dolphins provided some bright moments with 115 rushing yards, though it was not enough to keep pace with the 49ers' high-octane offense. Defensively, the 49ers were relentless, highlighted by Marques Sigle's two interceptions, which shifted the momentum in their favor and stifled any chance of a Miami comeback. Nick Bosa contributed with a sack, adding to the pressure on the Dolphins' offense. The turning point came when San Francisco capitalized on a key turnover, allowing them to extend their lead and put the game out of reach in the second half.