In a dominant performance, the Denver Broncos trounced the San Francisco 49ers 58-10 in Week 4 of the 2026 season. With this victory, Denver solidifies its position as a formidable contender in the league, showcasing their offensive firepower and tactical prowess against a struggling 49ers squad. Leading the offensive charge was quarterback Bo Nix, who threw for 288 yards and three touchdowns, demonstrating precision and poise throughout the contest. RJ Harvey also made headlines with an impressive 177 rushing yards, carving through the San Francisco defense with ease. Meanwhile, Courtland Sutton contributed significantly in the air with 71 receiving yards, proving to be a reliable target for Nix. Defensively, the Broncos were equally impressive, with Jonathon Cooper recording a sack that disrupted the 49ers' rhythm. The game's turning point came early in the second half when Lewis Cine intercepted a pass, setting the stage for a scoring drive that extended Denver's lead. The 49ers struggled to respond, as the Broncos’ defense stifled their attempts to mount any comeback, sealing a commanding victory.