In a tightly contested matchup, the San Francisco 49ers emerged victorious, defeating the Arizona Cardinals 24-17 in Week 3 of the 2026 season. The game featured playoff implications as both teams sought to establish momentum early in the season. Jacoby Brissett of the Cardinals showcased his arm strength, throwing for an impressive 319 yards and two touchdowns, while Marvin Harrison Jr. made a significant impact with 161 receiving yards. Despite the Cardinals' aerial assault, the 49ers' ground game was led by Kaelon Black, who managed 71 rushing yards, helping to balance the offensive attack. Defensively, the 49ers capitalized on key moments, with Marques Sigle's interception proving pivotal in stifling Arizona's momentum. Jimmie Ward's five tackles anchored a solid defensive effort, while Josh Sweat of the Cardinals tallied two sacks but couldn't prevent the 49ers from holding off the Cardinals' late-game push. The decisive moment came late in the fourth quarter when San Francisco's defense stepped up, forcing a turnover on downs that sealed the victory.