In a commanding performance, the Detroit Lions defeated the Buffalo Bills 42-9 in Week 2 of the 2026 season, showcasing their offensive prowess and solidifying their position early in the campaign. With both teams looking to establish momentum, the Lions made a definitive statement with this victory. Jared Goff led the charge for Detroit, throwing for 300 yards and four touchdowns, clearly demonstrating his effectiveness in the pocket. Jahmyr Gibbs complemented the aerial attack with a dominant ground game, racking up 126 rushing yards. While DJ Moore stood out for Buffalo with 110 receiving yards, it was not enough to keep pace with the Lions' explosive offense. Detroit's defense also played a crucial role in the win, highlighted by Alim McNeill's 1.5 sacks and Brian Branch's interception, which stifled any potential momentum for the Bills. The game's turning point came early in the second half when Branch's pick set up Goff's third touchdown pass, effectively putting the game out of reach and leaving the Bills struggling to recover.