In a commanding display, the Arizona Cardinals defeated the San Francisco 49ers 30-13 in Week 3 of the 2026 season. With this victory, the Cardinals solidified their position in the playoff race, while the 49ers struggled to find their rhythm on both sides of the ball. Drake Maye led the Cardinals' offense with a strong performance, throwing for 257 yards and keeping the chains moving effectively. Meanwhile, Jaylen Warren contributed significantly on the ground, racking up 82 rushing yards that helped maintain offensive momentum. For the 49ers, Justin Fields managed only one touchdown pass, while Puka Nacua stood out in the receiving game with 122 yards, but it wasn’t enough to spark a comeback. Defensively, the Cardinals made critical plays that turned the tide of the game, with Montez Sweat recording 1.5 sacks and putting constant pressure on Fields. Quentin Lake's interception was a pivotal moment, halting a 49ers drive and shifting momentum back to Arizona. Overall, the Cardinals' defense effectively stifled San Francisco's efforts, allowing the offense to capitalize and secure the win.