In a commanding performance, the San Francisco 49ers defeated the Washington Commanders 45-14 in Week 6 of the 2026 season. This victory solidifies the 49ers' position as a formidable contender, showcasing their offensive firepower and defensive prowess throughout the game. Tyler Shough led the way for San Francisco, throwing for 328 yards and four touchdowns, demonstrating his ability to connect with receivers downfield. Jakobi Meyers was the standout in the receiving corps, racking up an impressive 219 yards, while Bucky Irving contributed significantly on the ground with 81 rushing yards. Together, they fueled an explosive offensive showing that overwhelmed the Commanders' defense. Defensively, the 49ers were relentless, with Roquan Smith leading the team in tackles with nine. Andrew Van Ginkel added two sacks, putting pressure on the Washington quarterback and disrupting their offensive rhythm. The turning point came midway through the second quarter when Will Johnson intercepted a pass, setting up another touchdown that widened the gap and shifted momentum firmly in favor of San Francisco.