In a decisive victory, the Miami Dolphins defeated the San Francisco 49ers 35-12 in Week 2 of the 2026 season. With both teams looking to establish themselves early in the season, the Dolphins showcased their offensive firepower, leaving the 49ers searching for answers. Miami's quarterback Cam Ward delivered a standout performance, throwing for 349 yards and three touchdowns, leading the Dolphins' offensive attack. TreVeyon Henderson contributed on the ground with 69 rushing yards, while San Francisco's Omar Cooper Jr. shined in the receiving game, racking up 150 yards despite the loss. Defensively, Miami made key plays that shifted the momentum of the game, highlighted by an interception from Shaq Thompson and a sack from Quincy Williams. The turning point came in the second quarter when the Dolphins scored back-to-back touchdowns, establishing a commanding lead that the 49ers could not overcome. Overall, Miami's defense combined with their explosive offense proved too much for San Francisco to handle.