In a dominating performance, the San Francisco 49ers topped the Seattle Seahawks 41-0 in Week 12 of the 2026 season. With playoff implications on the line, San Francisco made a strong statement as they continue to assert their dominance in the league. Brock Purdy led the charge for the 49ers, throwing for 252 yards and a touchdown, showcasing his efficiency and poise throughout the game. Christian McCaffrey added to the offensive explosion with 80 rushing yards, while Brian Thomas Jr. contributed significantly in the passing game with 61 receiving yards. The 49ers' balanced attack proved too much for the Seahawks to handle. Defensively, San Francisco was relentless, highlighted by T.J. Watt's two sacks and Deommodore Lenoir's interception, which stifled any hopes of a Seattle comeback. The turning point came early in the second quarter when Lenoir's pick set up a quick touchdown for the 49ers, shifting the momentum squarely in their favor. The Seahawks struggled to find their rhythm, and the 49ers' defense capitalized at every opportunity, sealing a commanding victory.