In a commanding performance, the San Francisco 49ers defeated the Denver Broncos 63-33 in Week 4 of the 2026 season. With both teams looking to solidify their positions early in the year, the 49ers showcased their offensive firepower and left no doubt about their dominance on the field. Leading the charge was quarterback Patrick Mahomes, who threw for a staggering 567 yards and an impressive eight touchdowns. Mahomes found a reliable target in Trey McBride, who racked up 182 receiving yards and contributed significantly to the team's scoring efforts. The 49ers' offense was relentless, keeping the Broncos' defense on their heels throughout the game. Defensively, the 49ers were able to disrupt the Broncos' rhythm, with Jeremy Chinn leading the team with five total tackles and Kevin Winston Jr. adding a timely interception. The turning point came when Mahomes connected with McBride for a long touchdown, stretching the lead and demoralizing the Denver defense. Despite a solid rushing effort from Quinshon Judkins, the Broncos struggled to keep pace as the 49ers effectively controlled the game from start to finish.