In a dominant display, the Buffalo Bills crushed the New England Patriots 41-0 in Week 4 of the 2026 season. With playoff aspirations on the line, this victory solidifies the Bills' standing as a formidable contender, while the Patriots are left searching for answers after a dismal performance. Ty Simpson led the way for Buffalo, throwing for an impressive 299 yards and five touchdowns, showcasing his ability to exploit the Patriots' secondary. Brian Thomas Jr. emerged as his favorite target, racking up 157 receiving yards and finding the end zone multiple times. Saquon Barkley contributed on the ground with 31 yards, but it was the aerial attack that truly defined this game. Buffalo's defense was equally impressive, stifling the Patriots' offense at every turn. Harrison Smith not only recorded three total tackles but also made a significant impact with two sacks, while Denzel Ward's two interceptions further sealed New England's fate. The turning point came early in the second quarter when Ward's pick set up another touchdown, extending the lead to 28-0 and crushing any hopes of a Patriots comeback.