The San Francisco 49ers cruised past the Arizona Cardinals with a dominant 49-18 victory in Week 3 of the 2026 Madden franchise season. The win solidified the 49ers' standing as a formidable force early in the season, while the Cardinals were left searching for answers after a tough outing on the road. Brock Purdy put on a passing clinic, throwing for an impressive 396 yards and three touchdowns to lead the San Francisco offense. Christian McCaffrey contributed with 66 rushing yards, but it was Christian Kirk who stole the spotlight in the receiving game, hauling in 235 yards through the air. The 49ers' offensive prowess was on full display, making it a long day for the Arizona defense. Despite the lopsided score, the Cardinals' defense had some bright spots, with Germaine Pratt racking up 10 tackles and Budda Baker snagging an interception. However, San Francisco's relentless attack proved too much to handle. The game’s turning point came in the second quarter when Purdy connected with Kirk for a long touchdown pass, extending the lead and effectively putting the game out of reach for the Cardinals.