In a decisive Week 2 matchup, the Buffalo Bills topped the Detroit Lions with a final score of 35-16, showcasing their offensive prowess and setting the tone for the season ahead. The Bills improved to a strong start, while the Lions struggled to keep pace in a game that tested their resolve. Leading the charge for Buffalo was quarterback Josh Allen, who threw for 263 yards and one touchdown, effectively managing the game from the pocket. He was complemented by a dynamic performance from running back James Cook III, who racked up 94 rushing yards, and wide receiver DJ Moore, who made a significant impact with 127 receiving yards. This offensive trio proved too much for the Lions' defense to handle. Defensively, the Bills applied consistent pressure, with Dorian Williams recording a key sack that disrupted the Lions' rhythm at critical moments. While the Lions' D.J. Reed made his presence felt with 11 total tackles, it was Buffalo's ability to limit big plays and capitalize on opportunities that turned the tide. The game's turning point came in the second quarter when the Bills scored back-to-back touchdowns, creating a gap that the Lions could not bridge.