In a commanding performance, the San Francisco 49ers topped the Arizona Cardinals 42-21 in Week 3 of the 2026 season. With this victory, the 49ers solidify their early lead in the division and showcase their offensive prowess against a struggling Cardinals squad. Brock Purdy led the charge for San Francisco, throwing for 213 yards and three touchdowns, effectively spreading the ball and keeping the Arizona defense on its heels. Christian McCaffrey was a force on the ground, racking up 139 rushing yards, while Mike Evans added a key receiving threat with 92 yards, helping the 49ers maintain control throughout the contest. Defensively, the 49ers made their mark with a standout performance from Romello Height, who registered a sack, and Renardo Green, who came up with an interception. The turning point came in the second quarter when San Francisco scored two quick touchdowns, putting them ahead 28-14 and forcing the Cardinals to play catch-up for the rest of the game. Overall, the 49ers' balanced attack and opportunistic defense were the keys to their decisive win.