In a commanding performance, the Buffalo Bills topped the Detroit Lions 42-21 in Week 2 of the 2026 season, solidifying their early dominance in the league. With both teams looking to gain momentum, Buffalo came out strong, showcasing their offensive prowess and leaving Detroit struggling to keep pace. Leading the charge for the Bills was quarterback Josh Allen, who threw for 336 yards and three touchdowns, connecting effectively with receiver Jordan Addison, who racked up 124 receiving yards. The Lions’ Jahmyr Gibbs showed flashes of brilliance with 81 rushing yards, but it wasn’t enough to match Buffalo’s offensive firepower. Defensively, the Bills made their mark with two crucial sacks from Greg Rousseau and two interceptions from C.J. Gardner-Johnson, which helped shift the momentum decisively. The turning point came in the second quarter when Gardner-Johnson's first interception set up a quick touchdown, allowing Buffalo to stretch their lead and maintain control of the game. The Lions were unable to respond effectively, and Buffalo’s defense continued to stifle any comeback attempt.