In a high-octane matchup, the Arizona Cardinals defeated the Detroit Lions 42-28 in Week 5 of the 2026 season. Both teams entered the game looking to establish momentum, but it was the Cardinals who emerged victorious, solidifying their position in the playoff race. Sam Darnold led the way for Arizona, throwing for 262 yards and an impressive five touchdown passes, showcasing his ability to find the end zone. On the receiving end, Anthony Schwartz made his mark with 106 yards, providing Darnold with a reliable target. Meanwhile, Jahmyr Gibbs shone for Detroit with an explosive 200 rushing yards, but it wasn't enough to counter the Cardinals' offensive onslaught. Defensively, Arizona's ability to disrupt the Lions' rhythm proved crucial. Walter Nolen III recorded two sacks, putting pressure on the Detroit quarterback and contributing to a pivotal moment in the second half. Additionally, Starling Thomas V's two interceptions shifted the momentum squarely in Arizona's favor, allowing them to capitalize on mistakes and secure the win.